Sestini Matteo

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LinkedIn: https://www.linkedin.com/in/matteo-sestini-23065b101/

Office: Largo Lucio Lazzarino 2 56126 Pisa

 Ciclo: 39° ciclo

Ph.D. in Industrial Engineering

Curriculum: Chemical and Materials Engineering

Title of the PhD Project:

Innovative Approaches for the Design and Fabrication of Devices Based on Biomaterials through Additive Manufacturing and Computational Modelling

Supervisor(s)

Dr. Mario Milazzo, Prof.ssa Serena Danti

Abstract of the PhD project:

The rapid advancement in biomaterials and their applications in medical devices underscores the need for sophisticated design and fabrication techniques. Innovative methodologies combining additive manufacturing (AM) and computational modeling, including finite element analysis (FEA) and artificial intelligence (AI) can significantly contribute to optimize the design and production of custom-tailored biomaterial-based devices. In particular, AM allows for the creation of structurally and dimensionally stable manufacts with complex shapes for addressing the variability of patient-specific anatomical parts. However, a significant challenge is the discrepancy in mechanical properties observed between porous 3D printed objects and the same bulk material. Such issues are particularly critical in 3D printed medical devices that are designed for load-bearing applications. Concurrently, FEA can predict mechanical properties in various stress scenarios to determine the optimal composition and architecture of biomaterials. AI algorithms analyze vast datasets derived from previous design iterations and real-world outcomes to propose designs that optimize structural integrity and biological compatibility. Through the integration of these methodologies, the study aims to optimize the design and production processes to enhance the efficacy and safety of biomaterial-based devices, ultimately supporting the paradigm personalized medicine.

Teaching experience:

Publications

Favrin F., Zavagna L., Sestini M., Esin S., Milazzo M., Gallone G., Batoni G., Danti S. (2024). Antifouling properties of electrospun polymeric coatings induced by controlled surface morphology. Energy Environ. Mater. (accepted)

Scopus:

Conferences:

Sestini M., Milazzo, M., Gallone, G., Danti, S. (2023). Development of polymeric micropatterned alveolar-like coatings, 2nd Conference on Green Chemistry and Sustainable Coatings, June 28-30, 2023. Pisa, Italy.

Milazzo, M., Sestini, M., Gallone, G., & Danti, S. (2023). Bioinspired Polymeric Micro-Patterned Structures from Synergistic Additive Manufacturing Approaches. POLY-K 2023/Advances in polymer composites and nanocomposites. September 12-15, 2023. Terni, Italy.