https://www.linkedin.com/in/sara-tomasi-masoni-b9b29a212/
Ciclo: XXXVII
Curriculum: Ingegneria Chimica e dei Materiali
Title of the PhD Project: Boosting flow chemistry through machine learning and process intensification concept
Supervisors: Elisabetta Brunazzi, Chiara Galletti
Abstract of the PhD project:
The growing interest in microdevices stems from the possibility of implementing continuous operations with a large control of the operating conditions. The microreactor technology allows to reduce the quantities of reagents, waste, and energy consumption, leading to extremely efficient performances. The PhD project aims to apply process intensification concepts and machine learning techniques to microdevices. In particular, the research activity is focused on the characterization of the laminar flow inside an X-microdevice. First, numerical simulations and experiments are carried out to investigate the flow behavior inside the microdevice fed with reactive streams and to evaluate the mixing and reaction performance. Afterward, machine learning algorithms are used to recognize and classify the flow regimes inside the device. The same microdevice geometry was used to carry out experiments and numerical simulations on two different biphase systems to produce microparticles for drug delivery purposes. Two different production techniques are exploited: the segmentation method and the nanoprecipitation. Alginate particles are produced through the segmentation method, instead, chitosan nanoparticles are made via nanoprecipitation or “Ouzo effect”.
Teaching experience:
- Intensificazione di processo nell’ingegneria chimica, Elisabetta Brunazzi/Chiara Galletti (May 2022, 2 h)
- Intensificazione di processo nell’ingegneria chimica, Elisabetta Brunazzi/Chiara Galletti (May 2023, 10 h)
- Intensificazione di processo nell’ingegneria chimica, Elisabetta Brunazzi/Chiara Galletti (March 2024, 2 h)
Publications
Scopus: https://www.scopus.com/authid/detail.uri?authorId=57344169900
Orcid ID: 0000-0001-7266-1877
Articles
- Antognoli, S. Tomasi Masoni, A. Mariotti, R. Mauri, E. Brunazzi, C. Galletti, Investigation on steady regimes in a X-shaped micromixer fed with water and ethanol, Chemical Engineering Science, 2022.
- Antognoli, S. Tomasi Masoni, A. Mariotti, R. Mauri, M. V. Salvetti, E. Brunazzi, C. Galletti, Mixing improvement in a T-shaped micro-junction through small rectangular cavities, Micromachines, 2022. https://www.mdpi.com/2072-666X/13/2/159
- Tomasi Masoni, M. Antognoli, A. Mariotti, R. Mauri, M. V. Salvetti, C. Galletti, E. Brunazzi, Flow regimes, mixing and reaction yield of a mixture in an X-microreactors, Chemical Engineering Journal, 2022.
- Tomasi Masoni, A. Mariotti, M. Antognoli, C. Galletti, R. Mauri, M. V. Salvetti, E. Brunazzi, Reaction performance in T-, X- and arrow-shaped microdevices, Chemical Engineering Research and Design, 2023. https://www.sciencedirect.com/science/article/pii/S0263876223001806?pes=vor
- Marchetti, E. Siniscalco, M. Antognoli, S. Tomasi Masoni, R. Mauri, C. Galletti, E. Brunazzi, Using a microdevice to generate alginate droplets in sunflower oil, Chemical Engineering Transactions, 2023.
- Tomasi Masoni, A. Mariotti, M. Antognoli, C. Galletti, R. Mauri, M. V. Salvetti, E. Brunazzi, Prediction of the reaction yield in a X-micromixer given the mixing degree and the kinetic constant, Physical Review Fluids, 2024.
Conferences
- Steady and unsteady reactive flows in an X-microreactor, S. Tomasi Masoni, M. Antognoli, R. Mauri, C. Galletti, E. Brunazzi, Oral presentation, Gricu 2022 - Centralità dell’Ingegneria Chimica in un Mondo che cambia (Ischia, 3-6 July 2022).
- Flow features in a T-microchannel with cylindrical obstacles mixing water and ethanol, M. Antognoli, S. Tomasi Masoni, R. Mauri, C. Galletti, E. Brunazzi, Poster session, Gricu 2022 - Centralità dell’Ingegneria Chimica in un Mondo che cambia (Ischia, 3-6 July 2022).
- Flow regimes, mixing degree and reaction yield in microreactors, M. V. Salvetti, A. Mariotti, S. Tomasi Masoni, M. Antognoli, R. Mauri, E. Brunazzi, C. Galletti, EFMC14-14th European Fluid Mechanics Conference (Atene, 13-16 September 2022).
- Using a microdevice to generate alginate droplets in sunflower oil, L. Marchetti, E. Siniscalco, M. Antognoli, S. Tomasi Masoni, R. Mauri, C. Galletti, E. Brunazzi, Oral presentation, ICheaP16 – 16th International Conference on Chemical and Process Engineering (Napoli, 21-24 May 2023).
- Mixing and reaction efficiency in T-, X-, and arrow-shaped microreactors, S. Tomasi Masoni, A. Mariotti, E. Brunazzi, M. V. Salvetti, C. Galletti, R. Mauri, Oral presentation, 8th Micro and Nano Flows Conference (Padova, 18-20 September 2023).
- Production of Sodium Alginate droplets in an X-microdevice, S. Tomasi Masoni, A. Mariotti, C. Galletti, R. Mauri, M. V. Salvetti, E. Brunazzi, Oral presentation, ChemE-Med Conference (Salerno, 20 May 2024).